Janumet 50 + 500 mg Tablet

Janumet 50 + 500 mg Tablet is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to two antidiabetic drug classes: a DPP-4 inhibitor and a biguanide. Janumet 50 + 500 mg Tablet is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes.

How it works: Sitagliptin helps your body increase insulin release after meals and lowers the amount of sugar the liver releases by supporting the natural incretin system. Metformin lowers glucose made by the liver and helps your body use insulin better, so this tablet works in two ways to reduce blood sugar.

The Janumet 50 + 500 mg Tablet is the lower metformin-strength option in the Janumet 50 + 500 mg range and is often chosen when a doctor wants sitagliptin 50 mg with a smaller metformin dose. This can be useful for people who need combination treatment but may not tolerate higher metformin strengths as well, or for those whose treatment plan starts with a lower metformin amount before adjusting.

• Type 2 diabetes blood sugar control
• Used with diet and exercise
• May be used when one medicine alone is not enough
• Helps lower fasting and after-meal glucose
• Combination therapy for adults with type 2 diabetes

• Swallow the Janumet 50 + 500 mg Tablet whole with water; do not crush, chew, or split unless your doctor says otherwise.
• Take it with food to reduce stomach upset from metformin.
• Take it exactly as prescribed, usually once or twice daily depending on your doctor’s directions.
• Try to take it at the same time each day for consistency.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Keep following your diabetes meal plan, exercise plan, and blood sugar checks while taking this tablet.

Each Janumet 50 + 500 mg Tablet provides sitagliptin 50 mg plus metformin 500 mg. The exact schedule may be once or twice daily depending on your doctor’s plan, and the total daily dose should not exceed the amount your prescriber sets for you.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea, which can be more likely because this tablet contains metformin 500 mg
• Nausea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Upper respiratory symptoms such as a stuffy or runny nose

• Do not use Janumet 50 + 500 mg Tablet if you have severe kidney problems or a history of metformin-related lactic acidosis unless your doctor specifically approves it.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Tell your doctor if you have heart failure, liver disease, or a history of pancreatitis before starting this tablet.
• Your doctor may check kidney function before and during treatment because metformin is cleared by the kidneys.
• Be careful if you take other diabetes medicines, since combining them can increase the risk of low blood sugar.
• If you are scheduled for iodinated contrast imaging, ask your doctor whether to stop Janumet 50 + 500 mg Tablet temporarily.
• Use caution when driving or operating machinery if you get dizziness or low blood sugar symptoms.

• Insulin and sulfonylureas, which can increase the risk of low blood sugar
• Alcohol, which increases lactic acidosis risk with metformin
• Iodinated contrast dye used for some CT or X-ray tests
• Certain medicines that affect kidney function or raise metformin levels, such as cimetidine or some water pills
• Strong inducers or interacting diabetes medicines may require dose review by your doctor

Store Janumet 50 + 500 mg Tablet at room temperature in its original strip or box, away from moisture, heat, and out of reach of children.