Janumet 50 mg/1000 mg Tablet

Janumet 50 mg/1000 mg Tablet is a prescription medicine that combines sitagliptin 50 mg and metformin 1000 mg in each tablet. It belongs to the antidiabetic drug class and is used to help adults with type 2 diabetes lower blood sugar along with diet and exercise. This Janumet 50 mg/1000 mg Tablet is not for type 1 diabetes or diabetic ketoacidosis. Because it contains metformin 1000 mg, it is a higher-metformin-strength tablet that is chosen when a doctor wants that specific dose in one tablet.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar the liver makes by supporting natural incretin hormones. Metformin in this Janumet 50 mg/1000 mg Tablet lowers sugar made by the liver and helps your body use insulin better.

Janumet 50 mg/1000 mg Tablet is a stronger metformin-containing option than lower-strength Janumet tablets, so it is usually selected only after a doctor has assessed your blood sugar control and your ability to tolerate metformin. It can be helpful for people who need the 50 mg sitagliptin plus 1000 mg metformin combination in a single tablet, which may reduce pill burden. This strength is not meant to be split into a different regimen unless your prescriber specifically instructs you to.

• Type 2 diabetes mellitus
• Blood sugar control with diet and exercise
• Adjunct treatment when one medicine is not enough
• Combination therapy to reduce fasting and after-meal glucose

• Swallow the Janumet 50 mg/1000 mg Tablet whole with water; do not crush or chew it.
• Take it with meals to help reduce stomach upset from the metformin component.
• Take it exactly as prescribed, usually once or twice daily depending on your doctor’s plan.
• If you are also taking insulin or a sulfonylurea, follow your prescriber’s instructions closely because blood sugar can drop too low.
• Do not take an extra tablet to make up for a missed dose unless your clinician has told you to do so.
• Keep taking it regularly even if you feel well, because type 2 diabetes often has no symptoms.

Each Janumet 50 mg/1000 mg Tablet provides sitagliptin 50 mg plus metformin 1000 mg. The exact dosing schedule varies by patient, but it is commonly taken once or twice daily with meals; your doctor chooses the dose based on your current medicines, kidney function, and blood sugar results. Do not exceed the maximum daily amount prescribed by your clinician, and do not use this higher-strength tablet as a starting dose unless specifically directed.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea, which can be more noticeable with the 1000 mg metformin strength
• Diarrhea
• Stomach upset or abdominal discomfort
• Headache
• Upper respiratory symptoms like stuffy nose or sore throat
• Gas or bloating
• Low blood sugar when used with insulin or a sulfonylurea

• This Janumet 50 mg/1000 mg Tablet is a higher metformin-strength tablet, so stomach side effects may be more likely than with lower-strength tablets.
• Do not use if you have severe kidney disease, and your doctor may check kidney function before and during treatment.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Tell your doctor if you have a history of pancreatitis, heart failure, liver disease, or severe dehydration.
• Low blood sugar can happen more often if Janumet 50 mg/1000 mg Tablet is taken with insulin or a sulfonylurea; know the symptoms of hypoglycemia.
• If you need surgery, contrast dye imaging, or have vomiting/diarrhea with dehydration, ask your clinician whether to hold this medicine.
• Do not drive or operate machinery if you feel dizzy or if your blood sugar is low.

• Insulin or sulfonylureas, which can increase the risk of hypoglycemia
• Alcohol, which can increase the risk of metformin-related side effects and lactic acidosis
• Iodinated contrast dye used for some CT or X-ray tests
• Certain medicines that affect kidney function or blood sugar, including some diuretics and steroids

Store Janumet 50 mg/1000 mg Tablet at room temperature in its original strip or box, away from moisture and heat.