Macsita-M 50/500 Tablet

Macsita-M 50/500 Tablet is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used to help improve blood sugar control in adults with type 2 diabetes, along with diet and exercise. Macsita-M 50/500 Tablet is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body increase insulin release after meals and lowers the amount of sugar the liver makes by supporting natural incretin hormones. Metformin reduces sugar production in the liver and helps the body use insulin better, and as a tablet it delivers both medicines in one oral dose. Because Macsita-M 50/500 Tablet combines two medicines, it can lower blood sugar in two different ways with one tablet taken by mouth.

Macsita-M 50/500 Tablet contains a mid-strength combination dose, with a full 500 mg metformin component plus sitagliptin 50 mg in one tablet. This can suit people who need more glucose-lowering support than a low-dose tablet alone provides, but who do not need a higher metformin or sitagliptin amount. A doctor may choose this strength when the combination matches the patient’s blood sugar goals and tolerability.

• Type 2 diabetes
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Helps lower fasting and after-meal glucose

• Swallow Macsita-M 50/500 Tablet whole with water; do not crush, chew, or split unless your prescriber tells you to.
• Take it exactly at the time your doctor prescribes, often with meals to reduce stomach upset from metformin.
• Take it consistently each day to help steady blood sugar control.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Follow your meal plan and glucose-monitoring plan while using this tablet.

Each Macsita-M 50/500 Tablet provides sitagliptin 50 mg and metformin 500 mg. The usual schedule may be once or twice daily depending on the patient’s prior treatment, kidney function, and blood sugar response, but the prescriber decides the exact dose and timing. Do not take more than the amount your doctor prescribes; many sitagliptin-metformin regimens are limited by the daily metformin and sitagliptin totals, so dose changes should be made only by a clinician.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset
• Gas
• Headache
• Cold-like symptoms
• Mild low blood sugar if used with insulin or a sulfonylurea

• This is a prescription-strength diabetes tablet and should be used only if a clinician has evaluated you.
• Because it contains metformin, avoid heavy alcohol use and tell your doctor if you drink often.
• Tell your prescriber if you have kidney disease, liver disease, heart failure, dehydration, or a history of lactic acidosis.
• Use caution with driving or machinery if you feel dizzy or your blood sugar drops.
• You may need temporary dose changes if you become sick, dehydrated, or are having surgery or imaging with contrast dye.
• Report symptoms of pancreatitis right away, especially severe stomach pain with vomiting.
• If combined with insulin or a sulfonylurea, the risk of low blood sugar can be higher.

• Alcohol
• Insulin and sulfonylureas such as glimepiride or glipizide
• Iodinated contrast dye used for some CT scans or procedures
• Other medicines that can affect kidney function or blood sugar
• Strong enzyme-inducing medicines or interacting diabetes treatments may require closer monitoring

Store Macsita-M 50/500 Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.