Janumet XR CP Tablet

Janumet XR CP Tablet is a prescription diabetes medicine that combines sitagliptin and metformin in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used to help improve blood sugar control in adults with type 2 diabetes, along with diet and exercise. The exact amount of sitagliptin plus metformin in each Janumet XR CP Tablet is the strength shown on the package label. This tablet is not for treating type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the extra sugar made by the liver. Metformin reduces sugar production in the liver and helps the body use insulin better, and the tablet form is taken by mouth for steady daily blood sugar control.

Janumet XR CP Tablet is the labeled strength for this pack of 14 tablets, so it should be used only when a clinician has chosen this specific dose for you. Compared with lower-strength sitagliptin/metformin tablets, this strength may be selected when a patient needs the exact amount of both medicines in one tablet and can tolerate the metformin component.

• Type 2 diabetes
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Long-term glucose management

• Swallow Janumet XR CP Tablet whole with water; do not crush, cut, or chew it.
• Take it exactly as prescribed, usually with food to reduce stomach upset from metformin.
• Take it at the same time each day to help keep blood sugar control steady.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Do not change to a lower or higher strength of Janumet XR CP Tablet unless your doctor tells you to.

Each Janumet XR CP Tablet contains the sitagliptin plus metformin strength listed on the box, so it is a fixed-dose combination rather than separate tablets. It is usually taken once daily with food, but the exact schedule depends on the prescribed strength and your kidney function; your doctor decides the right dose and the maximum number of tablets per day for you.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset
• Gas
• Headache
• Runny nose or sore throat
• More stomach side effects may occur if this is a higher metformin strength

• Do not use for type 1 diabetes or diabetic ketoacidosis.
• Tell your doctor if you have kidney disease, because metformin-containing tablets may need dose adjustment or may not be appropriate.
• Avoid heavy alcohol use, which raises the risk of lactic acidosis with metformin.
• Use caution if you have heart, liver, or pancreas problems.
• Low blood sugar can happen more often if Janumet XR CP Tablet is combined with insulin or certain other diabetes medicines.
• Tell your doctor before imaging tests that use contrast dye, since metformin may need to be held temporarily.
• Be careful driving or operating machinery if you feel dizzy or if your blood sugar is low.

• Alcohol
• Insulin or sulfonylureas such as glimepiride or glyburide
• Iodinated contrast dye used for some scans
• Carbonic anhydrase inhibitors such as topiramate or acetazolamide
• Other medicines that affect blood sugar, including steroids or some diuretics

Store Janumet XR CP Tablet at room temperature in its original strip or box, away from moisture and heat, and keep it out of reach of children.