Sepamet-XR 50 mg/500 mg Tablet

Sepamet-XR 50 mg/500 mg Tablet is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to two anti-diabetic drug classes: a DPP-4 inhibitor (sitagliptin) and a biguanide (metformin). Together, Sepamet-XR 50 mg/500 mg Tablet is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. It is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar made by the liver in a glucose-dependent way. Metformin reduces sugar production in the liver and helps the body use insulin better, and the tablet form makes it easy to take the full combined dose in one swallow.

Sepamet-XR 50 mg/500 mg Tablet is a lower metformin dose than many combination tablets, so it may suit people who need sitagliptin 50 mg plus a modest amount of metformin rather than a higher metformin load. Because this is the 50 mg/500 mg strength, a doctor may choose it when starting or adjusting therapy to balance blood sugar control with stomach tolerability and overall dose needs.

• Type 2 diabetes
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Lowering fasting and after-meal blood sugar

• Swallow the Sepamet-XR 50 mg/500 mg Tablet whole with water; do not crush, chew, or split it.
• Take it exactly as prescribed by your doctor, usually with food to help reduce stomach upset from metformin.
• Take it at the same time each day to help you remember your dose.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Use the tablet as part of a diabetes plan that includes diet, exercise, and regular blood sugar checks.

Each Sepamet-XR 50 mg/500 mg Tablet provides sitagliptin 50 mg plus metformin 500 mg. The number of tablets per day depends on your prescribed regimen, kidney function, blood sugar response, and whether you are taking other diabetes medicines; your doctor decides the exact dose. Do not take more than prescribed, and do not change from this 50 mg/500 mg strength without medical advice.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset
• Gas or bloating
• Headache
• Upper respiratory symptoms
• Low blood sugar may occur more often if taken with insulin or a sulfonylurea

• Tell your doctor if you have kidney disease, since metformin-containing products may need dose changes or may not be appropriate.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Seek medical advice before surgery or imaging studies that use iodinated contrast, because this medicine may need to be paused.
• Use caution if you also take insulin or a sulfonylurea, since low blood sugar can be more likely.
• Do not use for type 1 diabetes or diabetic ketoacidosis.
• Report a history of pancreatitis, heart failure, or severe liver disease before starting treatment.
• If you feel shaky, dizzy, or weak, check your blood sugar and be careful driving or operating machinery.

• Insulin and sulfonylureas, which can increase the risk of low blood sugar
• Alcohol, which can raise the risk of metformin-related lactic acidosis
• Iodinated contrast dye used for some CT scans or X-rays
• Cimetidine and other medicines that can affect metformin levels or kidney clearance

Store Sepamet-XR 50 mg/500 mg Tablet at room temperature in the original strip/box of 10 tablets, away from moisture and heat.