Sitared-M XR 100/1000 Tablet

Sitared-M XR 100/1000 Tablet is a prescription diabetes medicine that combines sitagliptin 100 mg and metformin 1000 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used along with diet and exercise to help lower blood sugar in adults with type 2 diabetes. This specific Sitared-M XR 100/1000 Tablet is an extended-release, high-strength option for patients whose doctor has decided that both ingredients are needed at these amounts.

How it works: Sitagliptin helps your body increase insulin release after meals and reduces extra sugar made by the liver, while metformin lowers sugar production by the liver and improves how your body uses insulin. Because Sitared-M XR 100/1000 Tablet is extended-release, the medicine is released slowly from the tablet to provide blood sugar control over the day.

Sitared-M XR 100/1000 Tablet is a higher-strength tablet than Sitared-M Tablet 50/500 and Sitared-M XR100/500 Tablet, so it is not a starting dose for everyone. A doctor may choose this strength for someone who needs stronger blood sugar control and can tolerate the higher metformin amount in an extended-release form, which may be easier on the stomach than some immediate-release tablets for certain patients. The exact fit depends on your blood sugar readings, kidney function, and prior response to lower strengths such as Sitared-M 50/1000 Tablet.

• Type 2 diabetes mellitus
• Improving fasting blood sugar
• Lowering after-meal blood sugar
• Adjunct to diet and exercise
• Long-term glycemic control

• Swallow Sitared-M XR 100/1000 Tablet whole with water; do not crush, chew, or split it.
• Take it exactly as prescribed, usually once daily with a meal or as directed by your doctor.
• Take it at the same time each day to help you remember and keep blood sugar control steady.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Do not use this tablet to treat type 1 diabetes or diabetic ketoacidosis.
• Follow your meal plan and exercise plan, because this tablet works best with healthy lifestyle changes.

Each Sitared-M XR 100/1000 Tablet provides sitagliptin 100 mg plus metformin 1000 mg in an extended-release tablet. The dosing frequency is usually once daily, but your doctor may adjust how you take it based on your blood sugar, kidney function, and response to treatment; the maximum daily amount depends on whether you are also taking other diabetes medicines and on your medical status. Do not change the dose of Sitared-M XR 100/1000 Tablet on your own, especially because this is a higher-strength product compared with lower Sitared-M options.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• nausea
• diarrhea
• stomach upset
• gas
• headache
• upper respiratory symptoms
• decreased appetite

• This is a higher-strength Sitared-M XR 100/1000 Tablet, so it should be used only when a clinician has assessed that the dose is appropriate.
• Tell your doctor if you have kidney disease, because metformin-containing tablets may need to be avoided or adjusted.
• Limit alcohol, since heavy drinking increases the risk of serious metformin-related side effects.
• Use caution if you have a history of pancreatitis, heart failure, liver disease, or severe dehydration.
• Check with your doctor before having surgery or contrast dye imaging tests, as the medicine may need to be paused.
• Watch for low blood sugar if this tablet is combined with insulin or other diabetes medicines.
• Do not use for type 1 diabetes or diabetic ketoacidosis.

• Insulin or sulfonylureas, which can increase the risk of low blood sugar
• Alcohol, which can raise the risk of lactic acidosis with metformin
• Iodinated contrast dye used for some scans
• Certain medicines that affect kidney function or blood sugar, including some diuretics and corticosteroids

Store Sitared-M XR 100/1000 Tablet in its original strip or box at room temperature, away from moisture and heat, and keep it out of reach of children.