Siaglide-M OD 100/1000 Tablet PR

Siaglide-M OD 100/1000 Tablet PR is a prescription diabetes medicine that contains sitagliptin 100 mg and metformin 1000 mg in each extended-release tablet. It combines a DPP-4 inhibitor with a biguanide to help lower blood sugar in adults with type 2 diabetes. Siaglide-M OD 100/1000 Tablet PR is used along with diet and exercise to improve blood glucose control, and it is not for type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps your body release more insulin after meals and lowers the hormone that raises blood sugar, while metformin reduces sugar made by the liver and helps the body use insulin better. In this extended-release tablet form, the medicine is released gradually through the day to help keep blood sugar steadier.

Siaglide-M OD 100/1000 Tablet PR is the higher-strength sibling of Siaglide-M 50/500 Tablet PR, so it delivers a larger amount of both sitagliptin and metformin in one tablet. Because this is a stronger extended-release tablet, it is generally chosen for people who have already been assessed by a clinician and need more glucose-lowering effect than the lower strength can provide. It should not be used as a casual starting dose unless a doctor specifically prescribes it.

• Type 2 diabetes blood sugar control
• Used with diet and exercise
• May help lower fasting and after-meal glucose
• Sometimes prescribed when single-ingredient treatment is not enough
• Not used for type 1 diabetes or diabetic ketoacidosis

• Swallow Siaglide-M OD 100/1000 Tablet PR whole with water; do not split, crush, or chew the extended-release tablet.
• Take it exactly as prescribed, usually once daily, because this product is designed for once-a-day dosing.
• Take it with food or at the same time each day if your prescriber advises, to help reduce stomach upset.
• Do not take an extra tablet to make up for a missed dose; take the next dose at the regular time.
• If the tablet appears in your stool, that can happen with some extended-release medicines and does not always mean it did not work.

Each Siaglide-M OD 100/1000 Tablet PR provides sitagliptin 100 mg plus metformin 1000 mg as a prolonged-release tablet. This strength is typically taken once daily, but the exact schedule and whether it is appropriate for you are decided by your doctor based on your blood sugar, kidney function, and response to treatment. The maximum daily dose should not be exceeded, and this higher-strength tablet should not be combined with other sitagliptin- or metformin-containing products unless your prescriber tells you to.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea, which can be more noticeable with the 1000 mg metformin strength
• Nausea
• Stomach upset or abdominal discomfort
• Gas or bloating
• Headache
• Upper respiratory symptoms such as a stuffy or runny nose
• Mild dizziness

• Use caution if you have kidney disease, because metformin-containing products may need to be avoided or adjusted
• This higher-strength tablet is not the right choice for everyone starting treatment
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis
• Tell your doctor if you have heart failure, liver disease, or dehydration
• Be careful driving or operating machinery if you get dizziness or low blood sugar
• Let your clinician know if you are fasting, very ill, vomiting, or not eating normally
• Do not use for type 1 diabetes or diabetic ketoacidosis

• Alcohol
• Insulin or sulfonylureas such as glipizide or glyburide
• Iodinated contrast dye used for some imaging tests
• Other medicines that can raise blood sugar, such as corticosteroids or certain diuretics

Store Siaglide-M OD 100/1000 Tablet PR in its original strip or box at room temperature, away from moisture and excess heat.