Sitaglyn M 50/500 Tablet PR

Sitaglyn M 50/500 Tablet PR is an oral diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide combination used to help lower blood sugar in adults with type 2 diabetes. This product is meant to be used along with diet and exercise to improve glucose control, not to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body release more insulin after meals and reduces the amount of sugar the liver makes, which helps lower blood glucose when it is high. Metformin lowers sugar production by the liver and improves how the body responds to insulin, and the tablet form makes it easier to take both medicines together.

Sitaglyn M 50/500 Tablet PR is a fixed-dose tablet with a moderate metformin amount and a standard sitagliptin dose, so it may be chosen when a doctor wants both medicines in one tablet rather than separate pills. Because it is a PR tablet, it is designed for controlled release and should be used only for people whose prescriber has already decided this strength fits their glucose-lowering plan.

• Type 2 diabetes mellitus
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Support for long-term glucose management

• Swallow the Sitaglyn M 50/500 Tablet PR whole with water; do not crush, chew, or split it unless your prescriber specifically tells you to.
• Take it exactly as prescribed, usually with meals if your doctor advises, to help reduce stomach upset from metformin.
• Take it at the same time each day to keep your routine consistent.
• Do not take extra tablets to make up for a missed dose; follow your doctor’s instructions.
• If your doctor changes your dose, follow the new schedule carefully because this is a fixed-dose combination tablet.

Each Sitaglyn M 50/500 Tablet PR provides sitagliptin 50 mg plus metformin 500 mg in one prolonged-release tablet. Your doctor may prescribe it once daily or, in some treatment plans, as part of a different schedule based on your blood sugar response and kidney function; do not change the dose on your own. The maximum daily amount depends on your full treatment plan, but it should never exceed what your prescriber has ordered for you.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset
• Gas
• Headache
• Mild low blood sugar when used with insulin or sulfonylureas

• Use extra caution if you have kidney disease, because metformin-containing products may not be appropriate at certain kidney function levels.
• Avoid heavy alcohol use, since alcohol can increase the risk of lactic acidosis with metformin.
• Tell your doctor if you have a history of pancreatitis, heart failure, liver disease, or severe dehydration.
• This medicine can cause low blood sugar when combined with insulin or sulfonylureas, so symptoms like sweating, shaking, or dizziness should be taken seriously.
• Do not use Sitaglyn M 50/500 Tablet PR to treat type 1 diabetes or diabetic ketoacidosis.
• Tell your clinician about all medicines and supplements you take, especially before imaging tests that use iodinated contrast.
• Use caution when driving or operating machinery until you know how the medicine affects you, especially if you also take other glucose-lowering drugs.

• Alcohol
• Insulin
• Sulfonylureas such as glipizide or glyburide
• Iodinated contrast agents used for some imaging tests
• Medicines that can affect kidney function, such as certain diuretics or NSAIDs

Store Sitaglyn M 50/500 Tablet PR at room temperature in the original strip/box, away from moisture and excess heat.