Sitared-M Tablet 50/500

Sitared-M Tablet 50/500 is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used to help improve blood sugar control in adults with type 2 diabetes. Sitared-M Tablet 50/500 is taken by mouth as part of a treatment plan that also includes diet and exercise. It is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps your body raise insulin release after meals and lowers the amount of sugar your liver releases. Metformin lowers glucose production in the liver and helps your body use insulin better, and this tablet delivers both medicines together in one dose.

Sitared-M Tablet 50/500 is the lower metformin-strength sibling of Sitared-M 50/1000 Tablet, so it may suit people who need sitagliptin 50 mg with a smaller metformin dose. Compared with the XR products, this immediate-release tablet is meant to be taken more than once daily in some treatment plans and may feel different on the stomach because it is not extended-release. A doctor may choose Sitared-M Tablet 50/500 when starting combination therapy, adjusting dose, or when a lower metformin amount is better tolerated.

• Type 2 diabetes blood sugar control
• Add-on treatment with diet and exercise
• Combination therapy when one medicine is not enough
• Improving fasting and after-meal glucose levels

• Swallow Sitared-M Tablet 50/500 whole with water; do not crush, chew, or split unless your doctor tells you to.
• Take it with meals if your prescriber advises, since metformin is often easier on the stomach when taken with food.
• Take it at the same times each day to help keep your blood sugar steady.
• Follow the exact dosing schedule your doctor gives you; this strength is not a one-size-fits-all starting dose.
• Do not change to the XR strengths on your own, because extended-release tablets are taken differently.
• If you miss a dose, take it when you remember unless it is close to the next dose; do not double up.

Each Sitared-M Tablet 50/500 tablet contains sitagliptin 50 mg plus metformin 500 mg. Depending on your doctor’s plan, it may be taken once or twice daily, and the total daily metformin dose should not exceed the amount prescribed for you; your doctor decides the right schedule and any dose changes. This exact 50/500 strength is often used when a lower metformin amount is needed than with Sitared-M Tablet 50/1000 or the XR products.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Upper respiratory symptoms like a runny nose or sore throat

• This is a higher-strength combination tablet than a single diabetes medicine, so use it only if your doctor has specifically prescribed both ingredients together.
• Tell your doctor if you have kidney disease, because metformin-containing products may need dose adjustment or may not be appropriate.
• Avoid heavy alcohol use, since alcohol can increase the risk of lactic acidosis with metformin.
• Tell your prescriber if you have a history of pancreatitis or gallbladder disease.
• Use caution when driving or operating machinery if you feel dizzy or your blood sugar is low.
• If you are going to have surgery or certain imaging tests with iodinated contrast, your doctor may tell you to stop this medicine temporarily.
• Continue diet and exercise as part of treatment; this tablet does not replace lifestyle changes.

• Alcohol
• Insulin and sulfonylureas, which can raise the risk of low blood sugar
• Iodinated contrast dye used for certain CT scans or procedures
• Carbonic anhydrase inhibitors such as topiramate or acetazolamide, which can raise acidosis risk
• Medicines that affect kidney function or dehydration risk, including some diuretics

Store Sitared-M Tablet 50/500 in its original strip or box at room temperature, away from excess heat, moisture, and light, and keep it out of reach of children.