Sitared-M 50/1000 Tablet

Sitared-M 50/1000 Tablet is an oral diabetes medicine that contains sitagliptin 50 mg and metformin 1000 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide combination class and is used along with diet and exercise to help lower blood sugar in adults with type 2 diabetes. Sitared-M 50/1000 Tablet is not for type 1 diabetes or diabetic ketoacidosis. This strength provides a higher metformin amount than the 50/500 tablet, so it is intended for people whose doctor wants a stronger metformin dose in a single tablet.

How it works: Sitagliptin helps your body release more insulin after meals and lowers the amount of sugar the liver makes, while metformin reduces sugar production in the liver and helps your body use insulin better. In Sitared-M 50/1000 Tablet, the two medicines are combined in one tablet to help control blood glucose throughout the day.

Sitared-M 50/1000 Tablet is a higher-strength tablet in this brand family because it contains metformin 1000 mg, which is double the metformin in Sitared-M Tablet 50/500. Doctors may choose Sitared-M 50/1000 Tablet for adults who need more blood sugar control and can tolerate a stronger metformin dose, while still using the same sitagliptin 50 mg component. Compared with the XR products, this is the immediate-release tablet form, so it is typically taken more than once daily only if prescribed that way.

• Type 2 diabetes mellitus
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Reducing fasting and after-meal glucose levels

• Swallow Sitared-M 50/1000 Tablet whole with water; do not crush, split, or chew unless your prescriber tells you it is okay.
• Take it with meals to reduce stomach upset from metformin.
• Take it exactly at the times your doctor prescribed, because this immediate-release tablet is not the same as an XR tablet.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Keep taking it regularly even if you feel well, because high blood sugar often has no symptoms.

Each Sitared-M 50/1000 Tablet provides sitagliptin 50 mg plus metformin 1000 mg. The usual number of times per day depends on your prescribed regimen and kidney function; some patients take it once daily, while others may need a different schedule based on the total daily metformin dose and how they respond. Your doctor determines the exact dose and the maximum tablets per day for you, and this strength is meant for patients specifically assessed to handle the 1000 mg metformin tablet.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea, especially when starting treatment or if taken without food
• Diarrhea
• Stomach pain or bloating
• Headache
• Upper respiratory symptoms such as runny nose or sore throat
• Low appetite
• Mild dizziness

• Do not use Sitared-M 50/1000 Tablet for type 1 diabetes or diabetic ketoacidosis.
• This is a higher-strength metformin tablet, so it may be less suitable if you are sensitive to stomach side effects or if your doctor wants a lower starting dose.
• Tell your doctor if you have kidney disease, because metformin-containing products may need to be avoided or adjusted.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Use caution if you have heart failure, liver disease, dehydration, or a severe infection.
• Check your blood sugar regularly, especially when starting the tablet or changing dose.
• Be careful driving or operating machinery if you feel dizzy or if you also use insulin or another diabetes medicine that can cause low blood sugar.

• Alcohol
• Insulin and sulfonylureas such as glipizide or glimepiride, which can increase low blood sugar risk
• Contrast dye used for certain imaging tests
• Certain diabetes medicines or steroids that can raise blood sugar
• Drugs that affect kidney function, since metformin clearance may be reduced

Store Sitared-M 50/1000 Tablet in its original strip/box at room temperature, away from excess heat, moisture, and direct light.