Sitara-M 50/500 Tablet ER

Sitara-M 50/500 Tablet ER is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each extended-release tablet. It belongs to the DPP-4 inhibitor + biguanide class and is used to help lower blood sugar in adults with type 2 diabetes. This medicine is taken by mouth and works best along with diet, exercise, and regular blood sugar monitoring. Sitara-M 50/500 Tablet ER is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps your body release more insulin after meals and lowers the amount of sugar your liver makes by supporting natural hormone signals. Metformin reduces sugar production in the liver and helps your body use insulin better, and the extended-release tablet form is designed to provide a steadier effect over time.

Sitara-M 50/500 Tablet ER contains a lower sitagliptin dose than Sitara-M 100/500 Tablet ER, while keeping metformin at 500 mg. That makes this strength more suitable for people whose doctor wants a smaller sitagliptin dose or is adjusting therapy based on blood sugar response, kidney function, or tolerability. Because it is an extended-release tablet, it is designed to release metformin gradually rather than all at once.

• Type 2 diabetes mellitus
• Improving fasting and after-meal blood sugar
• Adjunct to diet and exercise
• May be used alone or with other diabetes medicines as prescribed

• Swallow the Sitara-M 50/500 Tablet ER whole with water; do not crush, split, or chew it.
• Take it exactly as your doctor prescribes, usually once daily with a meal to reduce stomach upset.
• Take it at the same time each day for consistent blood sugar control.
• If a dose is missed, take it when remembered unless it is almost time for the next dose; do not double up.
• Avoid stopping the tablet suddenly unless your prescriber tells you to do so.
• Check your blood sugar regularly as directed by your healthcare professional.

Each Sitara-M 50/500 Tablet ER contains sitagliptin 50 mg plus metformin 500 mg. This product may be taken once daily for some patients, but the exact schedule and whether it is enough by itself depends on your blood sugar readings, kidney function, and other medicines. Do not take more than your prescribed daily amount; your doctor determines the right dose for this specific strength.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea
• Nausea
• Stomach upset
• Gas or bloating
• Headache
• Runny nose or upper respiratory symptoms
• Low blood sugar when used with insulin or a sulfonylurea

• Sitara-M 50/500 Tablet ER is a higher-strength diabetes tablet than many starting regimens, so it should be used only if your doctor has assessed that this dose is appropriate.
• Do not use it for type 1 diabetes or diabetic ketoacidosis.
• Tell your prescriber about kidney disease, liver disease, heart failure, or a history of pancreatitis before taking it.
• Limit alcohol, because heavy drinking can raise the risk of lactic acidosis with metformin.
• Low blood sugar can happen more often if this tablet is combined with insulin or a sulfonylurea; know the warning signs.
• Do not crush or chew the extended-release tablet, or the medicine may be released too quickly.
• If you are having surgery, an imaging test with contrast dye, or severe dehydration, ask your clinician whether the tablet should be held temporarily.

• Alcohol
• Insulin and sulfonylureas such as glipizide or glyburide
• Iodinated contrast dye used for some imaging tests
• Strong medicines that affect blood sugar, such as corticosteroids or certain diuretics
• Other metformin-containing products

Store Sitara-M 50/500 Tablet ER in its original strip at room temperature, away from moisture, heat, and direct light.